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Metabolic Research Unit

Contact details:         

E:        metabolism@tcd.ie
P:        (01) 4284642

The principal focus of our studies is the pathophysiology of Type 2 diabetes.  We perform studies in adults, adolescents and children.  We study healthy volunteers as well as subjects with obesity, pre-diabetes and diabetes. 
We are mainly interested in the mechanisms underlying severe insulin resistance, particularly in young people.

The techniques we use include:

  • The glucose clamp protocol
  • Tracer studies for fuel turnover
  • Muscle biopsy
  • Exercise interventions and aerobic protocols
  • Diet interventions
  • MRI imaging
  • Magnetic resonance spectroscopy for fuel turnover
  • Current protocols include:

  • Mechanisms of non-response to aerobic exercise in early onset Type 2 diabetes
  • Dietary intervention and mechanisms underlying dietary effects on insulin resistance in early onset Type 2 diabetes.
  • Diabetes screening in construction workers
  • RISC: relationship between insulin resistance and cardiovascular disease
  • Clinical trials of new insulins, incretins and oral anti-diabetic agents
  • Our studies are funded from various sources including: the Health Research Board, EFSD, EASD, the EU Commission, the Diabetes Education and Research Fund, the Trinity Foundation.

    Contact: metabolism@tcd.ie | Sitemap | Last updated: Jul 14 2010 | Back to top
    Metabolism Research Unit, Department of Endocrinology, St James's Hospital, St James's Street, Dublin 8, Ireland | Tel:+353-1-416-2488