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NanoBiohazard Assessment
Project Title
Multi-modal toxicology and biohazard assessment of nanomaterials and their enabled products
Summary

Nanomaterials and their enabled products are increasingly attracting global attention due to their unique physicochemical properties. However, because of the raising health and safety concerns, nano-products and their components require a rigorous toxicology and biohazard assessment.

We have developed an in vitro, multi-modal, automated, simple, sensitive and robust experimental procedure to evaluate potential cytotoxicity that may be cause by nanomaterials and their enabled products. Utilizing this approach, we have analyzed the biocompatibility of silver nanowire based thin-films and various size silver nanowires on the cultured human cells.

Principal Investigator
Prof Jonathan N Coleman
Funding agency
SFI Funded CRANN - HP Collaboration
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Scientific Presentations
Verma N.K., Conroy J., Lyons P., Coleman J., O'Sullivan M., Kornfeld H., Kelleher D., Volkov Y. Multi-modal toxicology and biohazard assessment of nanomaterial-based thin films. SNNI's 6th annual Greener nano 2011 Conference, GN11: Advancing Applications and Reducing Risks. 2nd-3rd may, 2011, Cupertino CA, USA.
Conroy J., Verma N.K., Tormey S., Lyons P., Coleman J., O'Sullivan M., Komfeld H., Kelleher D., Volkov Y. An in vitro integrated ultrasensitive approach to biocompatibility analysis of silver nanowires. 3rd NanoImpactNet Conference: Building a bridge from NanoImpactNet to nanomedical research Feb 14, 2011, Lausanne, Switzerland.
Publications
Mohamed B.M., Verma N.K., Prina-mello A., Williams Y., davies A.M., Bakos G., Tormey L., Edwards C., Hanrahan J., Salvati A., Lynch I., Dawson K., Kelleher D., Volkov Y. Activation of stress-related signalling pathway in human cells upon Si02 nanoparticles exposure as an early indicator of cytotoxicity. Journal of Nanobiotechnology, 2011 9:29
Dr Navin Kumar Verma presented part of the research findings entitled "Multi-modal toxicology and biohazard assessment of nanomaterial-based thin films" at SNNI's 6th annual Greener Nano 2011 conference, GN11: Advancing Applications and Reducing Risks. 2nd-3rd May, 2011, Cupertino CA, USA. Details can be found at: http://www.greennano.org/GN11
Dr Navin Kumar Verma's Poster for Multi-modal toxicology and biohazard assessment of nanomaterial-based thin films
Ms Jennifer Conroy presented part of the research findings entitled "An in vitro integrated ultrasensitive approach to biocompatibility analysis of silver nanowires" at the 3rd NanoImpactNet Conference: Building a bridge from NanoImpactNet to nanomedical research Feb 14th, 2011 Lausanne, Switzerland. Details can be found at: http://www.nanotechia.org/events/3rd-nanoimpactnet-conference

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Last updated 28 September 2011 by Molecular Medicine (Email).